ADCs based on alpha-amanatin might help treat colorectal cancer For some right time, cancer scientists have considered the toxin, alpha-amanatin derived from death cap mushrooms, just as one cancer treatment. However, because of its penchant for causing liver toxicity, its potential as a highly effective therapy offers been limited. Experts at The University of Texas MD Anderson Cancer Center viewed antibody drug conjugates based on alpha-amanatin as one solution. They found that ADCs, when targeted at a gene called POLR2A, are effective in mouse studies in treating colorectal cancers highly.Svendsen will receive the award during the AAN’s 62nd Annual Meeting in Toronto, held April 10 through April 17, 2010. The Essey Award recognizes individuals who have made significant research contributions in the seek out the reason, prevention of, and cure for amyotrophic lateral sclerosis , also known as Lou Gehrig’s disease. The $25,000 prize is usually to be used toward continuing ALS research. ALS is a electric motor neuron disease which is usually seen as a the gradual degeneration and loss of life of motor neurons.